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He felt unaccustomed to the cold weather after living in a tropical climate.

not familiar or accustomed to something; lacking experience or practice in a particular situation.
She was unaccustomed to the quiet.
He felt unaccustomed to the heat.
This is unaccustomed to me.
unaccustomed to change
unaccustomed to the cold
unaccustomed to the noise
unfamiliar
inexperienced
new