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She felt a deep despair after losing her job.
A feeling of great sadness and loss of hope.
He sank into despair after the breakup.
The news filled her with despair.
They faced despair when their plans fell apart.
feel despair
overcome despair
express despair
hopelessness
despondency
gloom
He began to despair when he couldn't find his lost dog.
To lose all hope or confidence.
She started to despair when the rain ruined their picnic.
They began to despair after waiting for hours without news.
I could see him despair when he failed the exam.
despair over
despair at
in despair
lose hope
give up
despond