The main conflict in the story is between the hero and the villain.

The opposition of persons or forces that gives rise to the dramatic action in a drama or fiction.
The conflict was intense.
Avoid unnecessary conflict.
Their conflict ended peacefully.
internal conflict
armed conflict
avoid conflict
disagreement
clash
struggle
Their opinions often conflict with each other.

To be in opposition or disagreement with someone or something.
Our goals conflict.
Their stories conflict.
Plans can conflict.
conflict with
conflict arises
conflict resolution
clash
disagree
oppose
The siblings had a conflict over who would inherit their parents' old house.

A serious disagreement or argument, typically involving differing opinions or interests within a familial context.
The friends had a conflict about the game.
A small conflict arose over the last cookie.
Their conflict was about a silly misunderstanding.
avoid conflict
resolve conflict
internal conflict
disagreement
dispute
argument
The conflict between the two neighbors lasted for years.

A serious disagreement or argument, typically a protracted one.
The conflict caused much pain.
Avoid unnecessary conflict.
Their conflict was loud.
avoid conflict
resolve conflict
internal conflict
disagreement
dispute
quarrel